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Onscreen Chemistry: Best Hollywood Co-stars

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John Cusack & Joan Cusack

Being brother and sister doesn’t necessarily mean good co-stars, but it did in the case of John and Joan Cusack. Their careers started out interlinked, and stayed that way for the decades to come.

Both siblings got their start in Hollywood by starring in rom-coms Class and Sixteen Candles from the early ‘80s. 

Reflecting back on her career, Joan said she and her brother were just at the right place at the right time as they were lucky enough to cross paths with John Hughes early on in their careers.


John Cusack went on to become one of the most popular actors of his generation thanks to the roles in teen classics The Sure Thing and Say Anything

Joan was paving her own path, and even managed to score two Oscar nods for supporting turns in Working Girl and In & Out.

Despite the fact they were constantly exploring their singular passions, the siblings still kept on coming back to each other and starred in numerous projects together, including Grosse Pointe Blank and High Fidelity.


James Franco & Seth Rogen

It’s pretty much impossible to name a more epic bromance than the one between James Franco and Seth Rogen. They both get their big break after being cast in cult classic teen series Freaks and Geeks, and quickly found common ground.

Unfortunately, this show wrapped up after one season and the two actors went their separate ways. Seth Rogen was still moving in the comedy circles, while Franco tried to establish himself as a dramatic actor and found worldwide fame with a role in the Spider-Man franchise.


After a conversation with Judd Apatow, Franco decided to go back to his roots and Rogen welcomed him with open arms. They played the lead roles in comedy Pineapple Express back in 2008, and it was just the first in a long series of projects they made as a duo.

In addition to starring together in This is the End and The Interview, Franco and Rogen often made brief appearances in each other’s projects, making it clear they’re there for each other no matter what.

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